Hydroxypropyl methylcellulose (HPMC) is a common semi-synthetic cellulose derivative widely used in pharmaceutical, construction, food and other fields.
(1) Basic characteristics of HPMC
HPMC is a white powder that dissolves in water to form a viscous colloidal solution. It has good adhesion, stability and thickening properties, and can form a transparent film. The properties of HPMC depend on the degree of its methylation and hydroxypropylation, so there are different specifications and uses.
(2) Main application areas and usage of HPMC
1. Pharmaceutical industry
a. As a drug carrier and sustained-release agent
HPMC is often used as a sustained-release agent in drug preparations. In tablets and capsules, HPMC can form a stable film and control the drug release rate. When used, HPMC is mixed with the drug ingredients. After tableting or filling the capsule, HPMC can gradually release the drug in the gastrointestinal tract.
b. As a binder
In tablet production, HPMC is often used as a binder. When mixed with other ingredients, it can improve the strength and stability of the tablet.
c. As a suspending agent
In liquid medicines, HPMC can effectively prevent the drug ingredients from settling, thereby maintaining the uniformity of the drug.
2. Construction industry
a. As a thickener for cement mortar
In construction, HPMC is used to mix cement, sand and other materials to enhance the adhesion and construction performance of mortar. It can improve the water retention of mortar and prevent it from drying too quickly, thereby increasing the working time of mortar.
b. As an additive for tile adhesive
HPMC can be used as an additive for tile adhesive to increase the adhesion and construction performance of the adhesive and prevent bricks from falling off.
3. Food industry
a. As a food thickener and stabilizer
HPMC is often used as a thickener in food, such as in jams, jellies and beverages. It can increase the viscosity of the product and maintain the stability of the product.
b. As a food film former
HPMC can be used in the manufacture of food packaging film to form a transparent film to protect food.
4. Cosmetics Industry
a. As a thickener for cosmetics
HPMC is commonly used in cosmetics, such as facial cleansers, skin creams, etc., as a thickener to improve the texture and stability of the product.
b. As a film former
HPMC can form a transparent film and is used as a film former in skin care products, such as facial masks.
(3) Precautions for the use of HPMC
Solubility
The dissolution rate of HPMC is affected by temperature and stirring conditions. Ensure that the mixture is stirred evenly during dissolution to avoid agglomeration.
Concentration control
Adjust the concentration of HPMC according to application requirements. In pharmaceutical preparations, too high a concentration may affect the release rate of the drug; in building materials, too low a concentration may result in insufficient material performance.
Storage conditions
HPMC should be stored in a dry, cool place, avoiding high temperature and humidity to maintain its stability and effectiveness.
Compatibility
When applying HPMC, its compatibility with other ingredients needs to be considered, especially when used in drugs and foods, to ensure that no adverse reactions occur.
HPMC is a versatile cellulose derivative with a wide range of applications. From pharmaceuticals to construction, food to cosmetics, HPMC’s unique properties make it play an important role in a variety of products. When using it, it is necessary to select the appropriate specifications and concentrations according to specific application requirements, and pay attention to its solubility and storage conditions to ensure the effectiveness and stability of the product.