When hydroxypropyl methylcellulose (HPMC) products are directly added to water, they will coagulate and then dissolve, but this dissolution is very slow and difficult. There are three suggested dissolution methods below, and users can choose the most convenient method according to their usage:
1. Hot water method: Since hydroxypropyl methylcellulose (HPMC) does not dissolve in hot water, the initial stage of hydroxypropyl methylcellulose (HPMC) can be evenly dispersed in hot water, and then when it is cooled, three A typical method is described as follows:
1). Put the required amount of hot water into the container and heat it to about 70°C. Gradually add hydroxypropyl methylcellulose (HPMC) under slow stirring, the hydroxypropyl methylcellulose (HPMC) starts to float on the surface of the water, and then gradually forms a slurry, cool the slurry under stirring .
2). Heat 1/3 or 2/3 (required amount) of water in the container and heat it to 70°C. According to the method of 1), disperse hydroxypropyl methylcellulose (HPMC) to prepare hot water slurry ; Then add the remaining amount of cold water or ice water in the container, then add the above-mentioned hydroxypropyl methylcellulose (HPMC) hot water slurry to the cold water, and stir, then cool the mixture.
3). Add 1/3 or 2/3 of the required amount of water into the container and heat it to 70°C. According to the method of 1), disperse hydroxypropyl methylcellulose (HPMC) to prepare hot water slurry; The remaining amount of cold or ice water is then added to the hot water slurry and the mixture is cooled after stirring.
2. Powder mixing method: hydroxypropyl methylcellulose (HPMC) powder particles and an equal or greater amount of other powdery ingredients are fully dispersed by dry mixing, and then dissolved in water, then the hydroxypropyl methylcellulose Base cellulose (HPMC) can be dissolved without agglomeration. 3. Organic solvent wetting method: pre-disperse or wet hydroxypropyl methylcellulose (HPMC) with organic solvents such as ethanol, ethylene glycol or oil, and then dissolve it in water. At this time, hydroxypropyl methylcellulose ( HPMC) can also be dissolved smoothly.